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Safety and effectiveness of METAGLIP in pediatric patients have not been established.
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The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient.
Once you have resumed normal food and fluid intake, your doctor will tell you when you can start drug therapy again.
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Insulin therapy may be prescribed for patients with type 2 diabetes as well as any who are dependent on insulin.
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This fetotoxicity has been similarly noted with other sulfonylureas, such as tolbutamide and tolazamide.
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With two actions, the combination of glipizide and metformin helps your body cope with high blood sugar.
The drug has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions.
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Because aging is associated with reduced renal function, metformin should be used with caution as age increases.
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If patients have not satisfactorily responded to one to three months of concomitant therapy with the maximum dose of metformin and the maximum dose of an oral sulfonylurea, consider therapeutic alternatives including switching to insulin with or without metformin.
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Common causes of increased lactic acid production include (due to depletion of stores), heart failure, and respiratory disease (due to inadequate oxygenation of tissues); the most common cause of impaired lactic acid excretion is kidney disease.
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FDA Investigating Reports of Possible Increased Risk of Pancreatitis and Pre-Cancerous Findings of the Pancreas from Incretin Mimetic Drugs for Type 2 Diabetes.
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Patients should be cautioned against excessive alcohol intake, either acute or chronic, when taking Metaglip, since alcohol potentiates the effects of metformin hydrochloride on lactate metabolism.
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Know the signs of low blood sugar ( hypoglycemia) and how to recognize them: headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating.
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