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The presence of cell clusters or multiplets introduces large errors in viability measurements with clonogenic assays, and leads to overestimation of radiosensitivity () particularly in the low dose range of radiation.

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Clinical Practice Guideline Committee approval: February 27, 2015.

Other tests are typically performed on this tissue to determine whether the tumor is hormone receptor positive or negative.

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Normanno N, Campiglio M, De LA, Somenzi G, Maiello M, Ciardiello F, Gianni L, Salomon DS, Menard S (2002) Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth.

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