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At this time, it is not known whether Iressa will improve symptoms of NSCLC or help patients live longer.

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Prolonged contact with gefitinib at high concentration resulted in marked alterations in cell morphology.

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Cells were exposed to gefitinib for 48 h, irradiated and subsequently incubated with gefitinib for up to 7 days.

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Response rates were 71% in the phase I dose-expansion cohort of 63 patients and 66% in pooled results from two phase II studies of 411 patients.

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Moreover, data from another recent clinical trial have also revealed that orally active MS-209 plus cyclophosphamide, doxorubicin, and fluorouracil (CAF) therapy was well tolerated and improved the progression-free survival in patients with advanced or recurrent breast cancer who had not received previous therapy in comparison with CAF treatment alone.

The sustained antitumor effect due to immunological memory would obviate the requirement for prolonged, repetitive cycles of therapy.

It does sound like stage X disease.

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These may include: difficulty concentrating, fatigue, blue or sad mood, puffiness around the eyes, dry skin, water retention, weight gain, constipation and fatigue.

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Also, paclitaxel is exported from the p-glycoprotein and other ATP-binding cassette transporters placed at the luminal membrane of brain capillaries, as an explanation for the low concentrations of taxanes in the CNS.

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It's targeted directly at the tumors and does not affect surrounding tissue, hence the side effects are minimal and not like traditional radiation.

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Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer.

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