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These differences have no effect on the medical action of the drug whatsoever.
TRα transcripts are abundant in the heart, whereas TRα2 acts as a negative regulator because it functions by suppressing TRα1 transcription ().
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Suppressive therapy with levothyroxine for solitary thyroid nodules: a double-blind controlled clinical study and cumulative meta-analyses.
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After a month of taking them, the same god damn thing is starting to happen to me, out of nowhere, severe acne breakouts all over my body and face, ive noticed the hair just a bit reappearing above lip, and Im in huge panic right now, isnt the levothyroxine meant for UNDER production of thyroid?
On the contrary, the same polymorphism was not associated with a requirement for higher l-T 4 doses to normalize serum TSH levels in patients with autoimmune hypothyroidism ().
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Treatment with IL-2 is associated with transient painless thyroiditis in about 20% of patients ().
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