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Tapentadol: May enhance the CNS depressant effect of CNS Depressants.
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Have patient report immediately to prescriber signs of infection, severe injection site irritation, signs of high blood sugar (confusion, feeling sleepy, more thirst, hunger, passing urine more often, flushing, fast breathing, or breath that smells like fruit), signs of severe cerebrovascular disease (change in strength on one side is greater than the other, trouble speaking or thinking, change in balance, or change in eyesight), suicidal ideation, angina, tachycardia, severe dizziness, passing out, arrhythmia, behavioral changes, mood changes, tremors, difficulty moving, rigidity, bradycardia, dysphagia, difficulty speaking, difficulty focusing, seizures, vision changes, shortness of breath, drooling, bruising, bleeding, involuntary eye movements, enlarged breasts, sexual dysfunction, nipple discharge, amenorrhea, priapism, signs of neuroleptic malignant syndrome (fever, muscle cramps or stiffness, dizziness, very bad headache, confusion, change in thinking, fast heartbeat, abnormal heartbeat, or sweating a lot), or signs of tardive dyskinesia (unable to control body movements; tongue, face, mouth, or jaw sticking out; mouth puckering; and puffing cheeks) (HCAHPS).
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The exact mechanism of action (how the drug works in the body) is unknown.
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Treatment of patients with schizophrenia, particularly during a psychotic episode, may raise the issue of informed consent.
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In particular, no increase in cardiac mortality was found, which is somewhat reassuring with respect to the cardiac safety of ziprasidone.
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