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Two patients died due to intestinal lesions but in these cases immunosuppression had been reintroduced following partial remission of the disease.

CsA on colon carcinoma cells, we transfected CACO-2 cells with a plasmid coding for the peptide VIVIT, which was designed to compete with NFAT family members for the interaction site in calcineurin.

Immunosuppressive therapy and corticosteroids have, undoubtedly, had an impact on renal preservation in patients with severe lupus nephritis.

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Interestingly, neither ER or GR had any effect on repression of basal transcription by unliganded TR, suggesting that this blockade by the steroid hormone receptors had a selective effect on these two TR functions.

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The importance of this cycle to the development and maintenance of the tumor is made clear in cases where it is possible to eliminate the insult leading to chronic inflammation, especially in tumors from the gastro-intestinal tract.

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