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Johnson et al found the same incidence rate for all cancers in patients receiving insulin glargine as in patients not receiving the drug.

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The Genetics of Nonalcoholic Fatty Liver Disease: Role of Diet as a Modifying Factor.

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In 2010, the FDA required that GlaxoSmithKline develop a restricted access program for rosiglitazone under a Risk Evaluation and Mitigation Strategy (REMS).

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Lowering blood sugar is important because when blood sugar is high, inflammation can occur and destroy tissues.

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The good news is that pioglitazone reduced the risk of the secondary endpoint -- the bad news is that it increased the risk of heart failure and weight gain.

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Pioglitazone activates PPAR-γ and also causes partial activation of PPAR-α.

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Improvement of cardiovascular risk markers by pioglitazone is independent from glycemic control: results from the pioneer study.

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This warning is based on the study conducted by the University Group Diabetes Program (UGDP), a long-term, prospective clinical trial designed to evaluate the effectiveness of glucose-lowering drugs in preventing or delaying vascular complications in patients with non-insulin-dependent diabetes.

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Adherence to diet and exercise should continue to be stressed throughout treatment, because these lifestyle measures can have a large effect on the degree of diabetic control that patients can achieve.

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In the second approach, we used the study cohort to assemble a subcohort of patients starting pioglitazone or rosiglitazone between 1 January 2000 and 31 July 2013, with follow-up until 31 July 2014.

In clinical studies, hemoglobin levels were reduced primarily within the first 4 to 12 weeks of therapy but remained relatively constant thereafter.

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