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I have had CHRONIC cluster headaches since 1978. Of the dozens of medications I have been prescribed, the only one that has brought me sustained relief over the years is Cyproheptadine. I have been on it since 1984, 8-mg twice a day every day (except during my pregnancies when I stopped all medicines, reverting to indescribable pain). My cluster headaches are not cured by cyproheptadine, but the severity of pain is reduced to a tolerable level. No side effects. Also, I had an occipital nerve stimulator implanted in 2007, which continues to help tremendously. Best abortive for me has been Ultram, 3 tablets taken at onset of pain (I try to limit this to 1 or 2 times per day, taken at the times I most need to function well).

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