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The exercise portion of the test also provides prognostic information.
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These data suggest ranolazine may be capable of suppressing neuronal hyperexcitability during a seizure.
Beta blockers should be prescribed as initial drug therapy for relief of anginal symptoms in patients with stable ischemic heart disease (SIHD) (Class I B indication).
In a separate study, C max was increased between 40% and 50% in patients with mild, moderate or severe renal impairment compared to patients with no renal impairment, suggesting a similar increase in exposure in patients with renal failure independent of the degree of impairment.
Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy.
During episodes of angina pectoris, LV diastolic relaxation is impaired, myocardial stiffness is increased, and LV diastolic compliance is reduced.
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Beta blockers, such as atenolol, esmolol, metoprolol, or propranolol, are used to lessen the oxygen requirements of the heart by slowing the heart rate and lowering the arterial tension against which the heart is working.
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However, during severe myocardial ischaemia, E-4031 was profibrillatory, as it decreased VF threshold from control stenosis, whereas ranolazine increased it.
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Insulin (Ins, 100 n m) and forskolin (F, 10 μ m) were used as control.
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Because catecholamine-induced tachyarrhythmias are common in patients with heart failure and ischemic heart disease, the combination of ranolazine and dronedarone may reduce the incidence of arrhythmias in patients with these diseases.
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