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The move, on the heels of an identical price increase last year, thrust the Thousand Oaks-based biotechnology company into the growing controversy over accelerating drug prices.

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The routine application of CNIs to OLT has dramatically reduced rejection, morbidity associated with treatment of rejection and graft loss, and death caused by rejection.

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The company filed and received license applications for Stemgen, a drug that generated the growth of stem cells and led to a faster recovery of blood cells after chemotherapy, and made clinical trial progress on MGDF, KGF, leptin, and NESP.

These medications are also called “erythropoiesis-stimulating drugs.

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Most patients start mobilizing the extra fluid a week after OLT and then can be treated with diuretic therapy if their kidneys are functioning.