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The use of recombinant human erythropoietin to prevent carboplatin-induced anemia.

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Physician awareness of potential differences between biopharmaceuticals and biosimilars and the impact on safety and efficacy is critical for patient safety.

Investigational New Drug (IND) meetings covering 12 different biological reference products.

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Erythropoietin should be used only to treat anemia caused by chemotherapy -- not anemia due to other causes in patients with cancer.

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Cycle 1 - administered weekly for 7 weeks followed by a week of rest.

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For patients on peritoneal dialysis EPREX may be given twice a week.

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Tests to assess the relative risk of mAb candidates for cytokine release syndrome, innate immune system (dendritic cell) activation and immunogenicity in humans are also described.

Inflammation in mice that are hepcidin-deficient did not lead to hypoferremia, a finding that suggests that hepcidin may be centrally involved in the diversion of iron traffic through decreased duodenal absorption of iron and the blocking of iron release from macrophages that occurs in anemia of chronic disease ().

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The metal contaminant may have caused denaturation and aggregation, which in turn could have caused an immune response ().

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All randomized subjects who met enrollment criteria and received at least 2 cycles of study drug were considered evaluable for efficacy.

Current Management of Iron Deficiency Anemia in Inflammatory Bowel Diseases: A Practical Guide.

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This product is used in the treatment of anemia in those with Chronic Renal Failure, Zidovudine treated HIV Infection, and in cancer treatments.

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