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In an autoimmune disease like JM, however, the cells get active and they cannot stop.
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This risk may be dependent on dose and a number of other factors, including the condition being treated, other agents or treatment modalities used (including ), treatment intensity and length of treatment.
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All this has already been accomplished by the original manufacturer, and was subsequently reflected in the brand-name drug price.
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These drugs seem to increase the risk of leukemia (mainly AML), too, but the risk is not as great as with the alkylating agents.
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In JM, the immune system mistakenly targets muscles, skin and other tissues.
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