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I have been taking 30mg for over 90 days now. Due to other medications I was taking for lung cancer and COPD I was lucky to get 2 hrs sleep per night. The first couple of nights was wondering why I taking it. The 3rd night slept like a baby and have ever since. The increased food intake was great for me. I had started losing weight. Have not gained any but able to hold what I had. Works great for me.

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I've been on and off antidepressants for the last 10 or more years, including mirtazapine for the last 5 or so (can't really remember).

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Unlike the TCAs, mirtazapine showed no significant at 7 to 22 times the maximum recommended dose.

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The idea that antidepressant withdrawal is less severe than opioid withdrawal or lacks drug cravings is simply WRONG.

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The frequencies presented, therefore, represent the proportion of the 2796 patients exposed to multiple doses of mirtazapine who experienced an event of the type cited on at least 1 occasion while receiving mirtazapine.

In this context, it is interesting to note that mirtazapine also normalized the anxiety behavior.

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Mirtazapine is extensively metabolized by the liver, mainly via the cytochrome P450 system, and hepatotoxicity may be mediated by toxic intermediates of its metabolism.

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Two patients developed serotonin toxicity, having co-ingested 900 mg sertraline and 560 mg citalopram.

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The clearance of mirtazapine is reduced in elderly patients and in patients with moderate to severe renal or hepatic impairment.

All 3 patients recovered after mirtazapine was stopped.

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I've had people contact me who had such a terrible time that they went back on the drug, but I've had others say they were switched on to another antidepressant which helped the withdrawal, and didn't have as many side effects as Mirtazapine.

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Some individuals, especially those with bipolar disorder, have also noted a manic switch in mood or state of mania.

The researchers stated that if SSRIs increase suicide risk in some patients, the number of additional deaths is very small because ecological studies have generally found that suicide mortality has declined (or at least not increased) as SSRI use has increased.

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It is thought to be caused by a chemical imbalance in parts of the brain.

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Negative symptoms have long been recognized as a central schizophrenic feature, and they include blunted affect, poverty of thought content and speech, avolition or apathy and social withdrawal.

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Mirtazapine orally disintegrating tablets should be used with caution in patients with known cardiovascular or cerebrovascular disease that could be exacerbated by hypotension (history of myocardial infarction, angina, or ischemic stroke) and conditions that would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medication).

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