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Allopurinol was very very effective for me. Gout attacks made me nearly powerless but this medication changed things for the better. It noticed only one side effect, it was excessive sweating. Just a couple of quick steps can make me all wet. It is not very pleasant but it is definitely less confusing than having a gout attack.

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However, about 2% of individuals develop hypersensitivity reactions () and 20% of those are severe, including rash, toxic epidermal necrolysis, hepatitis, interstitial nephritis and death ().

One open cross-over CCT compared allopurinol 300 mg daily with allopurinol 100 mg three times daily ().

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In patients with decreased renal function or who have concurrent illnesses which can affect renal function such as hypertension and diabetes mellitus, periodic laboratory parameters of renal function, particularly BUN and serum creatinine or creatinine clearance, should be performed and the patient's dosage of Allopurinol reassessed.

Administration of Allopurinol generally results in a fall in both serum and urinary uric acid within 2 to 3 days.

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The reasons for withdrawal in the allopurinol groups in both trials were abnormal liver function tests, diarrhoea and a gout attack less than 24 hours after starting allopurinol.

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We also planned to compare the magnitudes of effect informally to assess possible differences in response to treatment by considering the overlap of the CIs of the summary estimates in the two subgroups with non-overlap of the CIs indicating statistical significance.

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Annals of the Rheumatic Diseases 2006; 65: 1312- 24.

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For the calculation of SMD, MD is divided by the standard deviation, resulting in a unit-less measure of treatment effect.

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