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Great medicine. I was taking 2 or 3 nitros daily. Took first Ranexa and pain just started going away. Now I take 1 or 2 nitros a week. I have 4 blockages at 100 % and 1 at 60% and I hardly have any angina. I learned my limits on what I can do. But I still can drive and work a little in our yard. Ranexa is a miracle.

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Although the effect of CYP2C9 inhibition on the efficacy of losartan is not clear, inhibitors of CYP2C9 are known to increase warfarin response, thus potentially increasing the bleeding risk if doses are not adjusted.

Observational studies also support a survival advantage for CABG in patients with double-vessel disease in the presence of severe or extensive ischaemia or severe angina.

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Administer medications as ordered and titrate according to patient response.

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Hazard ratios (HRs) and 95% confidence interval (CIs) were estimated by using a Cox proportional hazards regression model with effects for treatment and intention for early invasive strategy.

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All this has already been accomplished by the original manufacturer, and was subsequently reflected in the brand-name drug price.

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In animal models of diabetes, ranolazine lowered postprandial and basal glucagon levels, which were associated with a reduction in hyperglycemia and lowering of HbA 1c ().

It is important to keep in mind that generic and brand-name drugs do look more or less different.

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The overlapping presentation of coronary artery disease and DM is commonplace and is increasing with the prevalence of obesity worldwide.

As we discussed in section ii K, the proportion of glycolytic pyruvate being oxidized, and the subsequent intracellular acidosis that follows, may actually be more important with regard to functional outcome, rather than simply increasing glycolytic ATP production.

The narrowing of coronary arteries usually occurs slowly, and in response, new small collateral arteries have time to grow into the fields of the atherosclerotic arteries to help bolster the local oxygen supply.

The purpose of this explanatory analysis was to investigate the relationship between ST-segment depression and the rate-pressure product (RPP) during exercise to determine whether ranolazine's mechanism of action was related to a reduction in myocardial oxygen demand or preservation of myocardial oxygen supply.

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The multicenter study of enhanced external counterpulsation (MUST-EECP): effect of EECP on exercise-induced myocardial ischemia and anginal episodes.

CAD is a chronic process that begins during adolescence and slowly progresses throughout life.

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Application of 3 μM phenytoin (DPH) (, middle, DPH) or 30 μM lacosamide (LCM) (, bottom, LCM) produced a similar inhibition pattern of evoked action potentials.

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If a dose of RANEXA is missed, take the prescribed dose at the next scheduled time; do not double the next dose.

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Common side effects of Ranexa include dizziness; spinning sensation; nausea; vomiting; stomach pain; constipation; headache; dry mouth; weakness; ringing in your ears; swelling in hands, ankles, or feet; slow, fast, or irregular heartbeats; tremors; blood in the urine; and shortness of breath.