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Chloroquine inhibits the malignant phenotype of glioblastoma partially by suppressing TGF-beta.
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The re-emergence of CHIKV has also resulted in numerous outbreaks in several countries in the eastern hemisphere, with a threat to further expand in the near future.
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Eric Xu, Head of the VARI Center for Structural Biology and Drug Discovery, and his colleagues showed that chloroquine represses inflammation through synergistic activation of glucocorticoid signaling.
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Chloroquine could become an attractive option for use as a tool for malaria prevention in specific targeted populations, as it is safe and well tolerated, has a long duration of action to maximize the period of protection, and has a resistance profile that differs from that of most other drugs currently being used.
Observations from neurosyphilitic patients undergoing malaria therapy suggested that, on average, 1 gametocyte is produced per 156 asexual parasites (); in most endemic settings, fewer than 5% of the detectable parasites are gametocytes ().
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At the level of an individual with a very low gametocyte density, how are single male and female gametes able to fuse and mate in a mosquito blood meal with approximately 10 7 uninfected red blood cells?
Acute dystonic reactions usually occur within a few hours of taking a causative medication, but onset may be delayed a few days.
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