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Prebronchodilator spirometry was performed initially, followed immediately by the blinded administration of a study drug.

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The option of adding a second long-acting inhaled bronchodilator in patients with uncontrolled asthma has been supported by results from recent studies that examined the efficacy of tiotropium, a long-acting anticholinergic bronchodilator approved for the treatment of chronic obstructive pulmonary disease (COPD) but not for the treatment of asthma.

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The company has previously performed numerous trials to demonstrate its efficacy and safety, including four studies on its effects in patients with asthma on concomitant inhaled corticosteroids.

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National Heart Lung and Blood Institute estimate that an additional 12 million people have the disease but don't know it yet, doubling the national total.

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