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In preclinical monkey studies there was some evidence that the drug achieved its ocular hypotensive affect by acting on CNS receptors, but in humans it is thought to act peripherally suppressing aqueous production, and increasing uveoscleral outflow.

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This medication is used to treat open-angle glaucoma or high fluid pressure in the eye.

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Electronic indentation tonometry uses an electronic pen with a digital read-out.

With topical administration, conjunctival and localized skin allergic reactions are relatively common, whereas severe reactions, including death, are rare.

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