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BCIRG, Breast Cancer International Research Group; TCH, paclitaxel, cyclophosphamide, Herceptin.

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The most common adverse reactions in pancreatic cancer patients receiving TARCEVA 100 mg plus gemcitabine were fatigue, rash, nausea, and diarrhea.

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TKIs represent some of the earliest efforts at targeted therapeutics and the development of monoclonal antibodies, small molecule inhibitors, and multitargeted TKIs has laid the ground work for the development of other biologic agents.

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Resistance to radiotherapy is also commonly observed.

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Before acceptance on the expert panel, potential member authors from all guideline partnering organizations completed the CAP conflict of interest process, whose policy and form requires disclosure of material financial interest in, or potential for benefit of significant value from, the guideline's development or its recommendations beginning 12 months prior and ending when the guideline was submitted for publication (see “”).

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This increase coincides with the widespread introduction of EGFR TKIs into the clinic; gefitinib was FDA approved for use in NSCLC in May 2003, and erlotinib was FDA approved in November 2004 (B).

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Recent phase II clinical studies showed that gefitinib shows antitumor activity in patients with breast cancer when used as a monotherapy or in combination with others drugs, such as docetaxel or anastrozole (), indicating that gefitinib can potentiate the antiproliferative effects of antiestrogens and conventional chemotherapeutic agents.

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CI-1033 (8 μM) combined with SN-38 (10 nM) enhance the effect of SN-38 to delay T98G cells at G2-M phase.

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