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Semi-mechanistic Model for the Effects of a Novel Glucagon Receptor Antagonist on Glucagon and the Interaction Between Glucose, Glucagon, and Insulin Applied to Adaptive Phase II Design.

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Metformin is the only anti-diabetic drug proven to prevent the Cardiovascular Complications of Type Two Diabetes.

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All samples in which Intestinibacter was detected fall among the 9 out of 30 untreated rather than the 21 out of 30 metformin-treated samples, consistent with severe depletion under treatment; whereas Escherichia abundances increase under treatment, likewise consistent with observations from the main data set.

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Overt diabetes was diagnosed in two subjects before treatment (elevated baseline fasting glucose and insulin values) and in two placebo-treated subjects (one at week 12 and the other after study completion).

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The nurse specialized in diabetes care, and if necessary, gave advice to adjust the insulin dose or try another insulin mixture (e.

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