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These seminal studies on the direct effects of NO on glucose metabolism were followed by others that described inhibitory actions of NO on phosphofructokinase of pancreatic islets () and an indirect stimulatory action of NO on 6-phosphofructo-2-kinase in neurons ().

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This initiative continues the earlier work of the International Association for the Study of Pain (IASP) and the AAPM into raising physician and nurse awareness of the need for humane treatment of pain and promoting the doctrine that pain is both unnecessary and avoidable with appropriate drug treatment (AGS Panel, 1998).

Taken together, there is evidence from small clinical and animal studies to support the concept that acutely stimulating myocardial carbohydrate oxidation and inhibiting myocardial fatty acid oxidation can rapidly improve LV function and mechanical efficiency.

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The myocardial uptake of the fatty acid analog 125I-iodophenyl 9-methylpentadecanoic acid was increased in the volume-loaded animals, suggestive of a greater fatty acid uptake and oxidation.

Management of postmenopausal osteoporosis includes nonpharmacologic treatment (e.

University of Florida Health Science Center, opened in 1956 with a mission to increase Florida's supply of highly qualified physicians, provide advanced health-care services to Florida residents and foster discovery in health research.

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In the 6-week ERICA trial of chronic angina patients on background therapy of amlodipine 10 mg QD (44% treated with long-acting nitrates) initially started on ranolazine 500 mg twice daily for 1 week and then uptitrated to 1000 mg twice daily as tolerated, there were no cases of syncope.

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Less than 5% of ranolazine is excreted unchanged by the kidney while the remainder is extensively and rapidly metabolized mainly by CYP3A4 enzymes in the liver and, to a lesser extent, by CYP2D6.

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Effects of ranolazine on disease-specific health status and quality of life among patients with acute coronary syndromes: results from the MERLIN-TIMI 36 randomized trial.

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As a result, a decrease in fatty acid β-oxidation could theoretically contribute to lipid-induced cardiac pathology, and the acceleration of fatty acid β-oxidation may lessen the potential for lipotoxicity.

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Before and at intervals during and after the dosing period, blood samples were drawn for ranolazine assay and blood pressure, heart rate, ECG and symptoms were monitored throughout.

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Recommended initial dosing is 500 mg twice daily; this may be escalated to a maximum dose of 1000 mg twice daily, based on disease response.

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