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Symptoms and signs may result from the location of the primary local invasion or compression of adjacent thoracic structures, distant metastases, or paraneoplastic phenomena.

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The BCR-ABL tyrosine kinase, the product of the chimeric gene produced by the Philadelphia (Ph) chromosome, is the molecular abnormality that causes chronic myeloid leukemia (CML).

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KT reviewed the medical records and imaging findings, drafted the manuscript and coordinated the submission.

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A generic drug simply means that the drug is not made by the original manufacturer, the chemical is exactly the same.