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Docetaxel and pemetrexed have been approved by the US Food and Drug Administration (FDA) in this clinical setting, but other drugs (eg, gemcitabine, vinorelbine), if not used in the first-line regimen, may result in similar palliation and clinical benefit.

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Evidence appeared to support the author's conclusion, but the lack of reporting of trial quality and review methods made it difficult to assess its reliability.

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If the cytologic result is negative, continue chemotherapy at the same rate of twice a week for 2 more weeks, then decrease the frequency to twice a week for 1 week a month, followed by further CSF monitoring every two months.

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Cytologic samples are also suitable for EGFR and ALK testing, with cell blocks being preferred over smear preparations.

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Although postmarketing surveillance in Japan showed that approximately one quarter of gefitinib-treated patients were 75 years of age or older, the study by Maemondo et al.