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Dose intensification with a combination of cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) every 2 weeks improves outcomes in patients older than 60 years with diffuse large B-cell lymphoma compared with CHOP every 3 weeks.

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Because pathological antibody production is characteristic of a number of systemic diseases that affect the kidneys and is a problem in renal transplantation, rituximab has been used to treat a number of these disorders, although the exact mechanisms by which it exerts its effect remain unclear ().

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