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The fibrate induced additional, but moderate, LDL cholesterol reduction, especially by fenofibrate (), and the substantial reduction in TG levels, the shift to a less-dense and thus less-atherogenic LDL particle profile, as well as the significant increase in HDL cholesterol levels () substantially improve the efficacy of combination treatment.

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In early-phase studies in humans, the drug increased HDL cholesterol by 60 to 100% at the same time that it lowered LDL cholesterol by up to 20%.

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Fibrates in CVD: a step towards personalised medicine.

Study did not reach primary end point (dose response for reduction in systolic blood pressure).

People with diabetes are at higher risk for gallstones and have a higher-than-average risk for acalculous gallbladder disease (without stones).

Conversely, in a substudy of the ACCORD trial, cognitive impairment at baseline or decline in cognitive function during the trial was significantly associated with subsequent episodes of severe hypoglycemia ().

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Lipid management in the context of good glycaemic control using simvastatin (20 mg daily for primary prevention and 40 mg daily for secondary prevention) in all patients with the addition of fenofibrate or placebo.

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Treatment with fenofibrate should be initiated at a dose of 48 mg per day in patients having mild to moderately impaired renal function, and increased only after evaluation of the effects on renal function and lipid levels at this dose.

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