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After having arthroscopic knee surgery, I developed a persistent skin infection (cellulitis) at the surgery site. I spent a month on different antibiotics that didn't clear the infection (cephalexin, clindamycin, and ciprofloxacin) and was finally admitted to the hospital for another surgery and treatment with IV antibiotics (vancomycin, zosyn). Zyvox has the same coverage as vancomycin but can be taken orally, which allowed me to leave the hospital after a week. I'm about finished with a 15 day course of Zyvox and the infection seems cleared. I haven't experienced many side effects - I've had a headache and felt a little tired and dizzy, but that's it.