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I have been seeing my dermatologist for 3 years and I have tried every common antibiotic and topical cream to no avail. I have been on spironolactone (in conjunction with Benzaclin gel, Cetaphil wash twice a day and tetracycline, which I have been on for a year and a half) for the past month and it has been a God-send. I recently turned 20 and my acne had never been worse. It changed from pustules to cystic nodules that would take weeks to fight back and hours spent crying in front of the mirror. I would refuse to leave the house and my boyfriend and mother became increasingly concerned. Since beginning this medicine my skin has cleared and I couldn't be happier! I would definitely recommend this medicine.