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Patients with large-volume disease can be safely and successfully treated in a staged fashion in the operating room and in the office, minimizing the risk for anal stenosis and development of cancer.

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As a lesion-directed therapy, cryosurgery fails to address the issue of “field cancerization” associated with UVR damage.

Vaccine immunotherapy requires the body to build up its own defenses.

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Differences in neurotoxic effects and abdominal discomfort between the two groups have been reported elsewhere.

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Additionally, the greater the amount of imiquimod in the formulation, the faster and the greater the total amount of imiquimod is released, evidencing that the amount in and the rate of release from the formulations are imiquimod concentration dependent.

Causes include primary or superimposed infection with microorganisms such as Candida albicans, staphylococci, or streptococci; poor hygiene; drooling of saliva; overclosure of the jaws in patients without teeth or with ill-fitting dentures; riboflavin deficiency; or other causes.

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Infants born to hepatitis B-infected mothers have a greater-than-95% chance of being protected against the virus if they receive the first dose of vaccine and immune globulin within 12 hours of birth.

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Personal subscribers to Nature Reviews Immunology can view this article.

Immunotherapy for Head and Neck Squamous Cell Carcinoma.

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Former therapy options included needle diathermy occlusion and polidocanol sclerotherapy.

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The mechanism of action of imiquimod, a toll-like receptor-7 agonist, is believed to be related to its ability to augment both the innate and acquired arms of immunologic response.

Before treatment is considered, biopsy is often needed to confirm the diagnosis and to rule out other possibilities, including basal cell carcinoma.

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The lower series of photographs shows before, during, and after effects of imiquimod treatment of actinic keratosis and basal cell skin cancers.

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